--- /dev/null
+From 55f5d8ce51ad999123a779f31fcf0fecd60de9e6 Mon Sep 17 00:00:00 2001
+From: Andreas Heger <andreas.heger@gmail.com>
+Date: Mon, 21 Mar 2016 21:10:04 +0000
+Subject: [PATCH] {AH} create empty config.h for samtools if it does not exist,
+ fixes #245
+
+---
+ setup.py | 12 +++++++++++-
+ 1 file changed, 11 insertions(+), 1 deletion(-)
+
+diff --git a/setup.py b/setup.py
+index 7b59b69..2f00c37 100644
+--- a/setup.py
++++ b/setup.py
+@@ -155,7 +155,7 @@ def run_configure(option):
+ outf.write(
+ "/* empty config.h created by pysam */\n")
+ outf.write(
+- "/* conservative compilation options */")
++ "/* conservative compilation options */\n")
+
+ if HTSLIB_LIBRARY_DIR:
+ # linking against a shared, externally installed htslib version, no
+@@ -259,6 +259,16 @@ def run_configure(option):
+ "adding shared libcurl and libcrypto")
+ external_htslib_libraries.extend(["curl", "crypto"])
+
++# create empty config.h files if they have not been created automatically
++# or created by the user:
++for fn in "samtools/config.h", "htslib/config.h":
++ if not os.path.exists(fn):
++ with open(fn, "w") as outf:
++ outf.write(
++ "/* empty config.h created by pysam */\n")
++ outf.write(
++ "/* conservative compilation options */\n")
++
+ parts = ["samtools",
+ "bcftools",
+ "htslib",
--- /dev/null
+# Copyright 1999-2016 Gentoo Foundation
+# Distributed under the terms of the GNU General Public License v2
+# $Id$
+
+EAPI=6
+
+PYTHON_COMPAT=( python2_7 python3_{4,5} )
+
+inherit distutils-r1 python-r1
+
+DESCRIPTION="Python interface for the SAM/BAM sequence alignment and mapping format"
+HOMEPAGE="https://github.com/pysam-developers/pysam http://pypi.python.org/pypi/pysam"
+SRC_URI="https://github.com/pysam-developers/${PN}/archive/v${PV}.tar.gz -> ${P}.tar.gz"
+
+LICENSE="MIT"
+SLOT="0"
+KEYWORDS="~amd64 ~x86"
+IUSE=""
+
+RDEPEND="=sci-libs/htslib-1.3*"
+DEPEND="${RDEPEND}
+ dev-python/cython[${PYTHON_USEDEP}]
+ dev-python/setuptools[${PYTHON_USEDEP}]"
+
+PATCHES=(
+ "${FILESDIR}/${P}-missing-config.h.patch"
+)
+
+src_prepare() {
+ default
+
+ export HTSLIB_INCLUDE_DIR=${EPREFIX}/usr/include
+ export HTSLIB_LIBRARY_DIR=${EPREFIX}/usr/$(get_libdir)
+ export HTSLIB_CONFIGURE_OPTIONS="--disable-libcurl"
+
+ sed -e "/ext\.extra_link_args += \['-Wl,-rpath,\$ORIGIN'\]/d" \
+ -i cy_build.py || die
+ sed -e '/runtime_library_dirs=htslib_library_dirs/d' \
+ -i setup.py || die
+}
+
+src_compile() {
+ # TODO
+ # empty compile, as the build system runs the whole build again in install
+ :
+}