From bec8bd83d70238c4ff7065171da4a78a9c54e2a6 Mon Sep 17 00:00:00 2001
From: "W. Trevor King" <wking@tremily.us>
Date: Tue, 11 Jun 2013 23:38:24 -0400
Subject: [PATCH] root.bib: Add notes for the salt papers

---
 src/root.bib | 18 ++++++++++++++++++
 1 file changed, 18 insertions(+)

diff --git a/src/root.bib b/src/root.bib
index b02bb3a..b4d1b73 100644
--- a/src/root.bib
+++ b/src/root.bib
@@ -10454,6 +10454,8 @@
     1-40, A beta 1-42 fibrils are also defibrillized in the presence
     of millimolar concentrations of Ca2+. These studies suggest that
     metal cations can defibrillize the fibrils of synthetic A beta.},
+  note = {From page 806, ``The exact mechanism by which these metal
+    ions affect the fibrillization of A$\beta$ is not known.''},
 }
 
 @article{ friedman05,
@@ -10605,6 +10607,13 @@
     developed that depend upon direct ion-macromolecule interactions
     as well as interactions with water molecules in the first
     hydration shell of the macromolecule.},
+  note = {A quick pass through Hofmeister history, but no discussion
+    of cations (``A complete picture will inevitably involve an
+    integrated understanding of the role of cations (including
+    guanidinium ions) and osmolytes (such as urea and tri-methylamine
+    N-oxide) as well. There has been some progress in these fields,
+    although such subjects are generally beyond the scope of this
+    short review.'').},
 }
 
 @article{ isaacs06,
@@ -10656,6 +10665,8 @@
     impaired intraneuronal calcium regulation in the aging brain and
     Alzheimer disease, may play an important role in the onset of
     amyloid-related pathology.},
+  note = {Physiological levels of \NaCl\ are $\sim 150\U{mM}$.  \Ca\
+    is $\sim 2\U{mM}$.},
 }
 
 @article{ itkin11,
@@ -10719,6 +10730,8 @@
     fibrils. Overall, these results led us to conclude that calcium
     ions stimulate the formation of oligomers of A$\beta$(1-40), that
     have been implicated in the pathogenesis of AD.},
+  note = {$2\U{mM}$ of \Ca\ is the \emph{extracellular} concentration.
+    Cytosol concetrations are in the $\mu$M range.},
 }
 
 @article{ zidar11,
@@ -10768,6 +10781,8 @@
     N-terminal parts of the fibril, whereas aggregation at higher
     ionic strength is suggested to be driven by the hydrophobic
     interaction.},
+  note = {Only study \NaCl\ over the range to $308\U{mM}$, but show a
+    general decreased hydrogen bonding as concentration increases.},
 }
 
 @article{ miao11,
@@ -10813,6 +10828,9 @@
     with high affinity and specificity at biologically-relevant
     concentrations.  Interestingly, the binding is found to be both
     salt- and residue-specific.},
+  note = {They suggest that for low concentrations ($<100\U{mM}$),
+    protein-ion interactions are mostly electrostatic.  The Hofmeister
+    effects only kick in at higher consentrations.},
 }
 
 @article{ dyson05,
-- 
2.26.2