From 8140e0220cd9088087c7a49b8b093ed540f6cd0e Mon Sep 17 00:00:00 2001 From: "W. Trevor King" Date: Thu, 25 Apr 2013 13:10:31 -0400 Subject: [PATCH] introduction/main.tex: Expand on the landscape/pathway distinction --- src/introduction/main.tex | 15 +++++++++------ 1 file changed, 9 insertions(+), 6 deletions(-) diff --git a/src/introduction/main.tex b/src/introduction/main.tex index f55709d..2fad3fd 100644 --- a/src/introduction/main.tex +++ b/src/introduction/main.tex @@ -52,15 +52,18 @@ remarkably difficult. \label{sec:energy-landscape} % the free energy landscape -Folding a protein via a brute force sampling of all possible -conformations is impossibly inefficient, due to the exponential -scaling of possible conformations with protein length, as outlined by -\citet{levinthal69}. This has lead to a succession of models -explaining the folding mechanism. For a number of years, the +Finding a protein's lowest energy state via a brute force sampling of +all possible conformations is impossibly inefficient, due to the +exponential scaling of possible conformations with protein length, as +outlined by \citet{levinthal69}. This has lead to a succession of +models explaining the folding mechanism. For a number of years, the ``pathway'' model of protein folding enjoyed popularity (\cref{fig:folding:pathway})\citep{levinthal69}. More recently, the ``landscape'' or ``funnel'' model has come to the fore -(\cref{fig:folding:landscape})\citep{dill97}. +(\cref{fig:folding:landscape})\citep{dill97}. Both of these models +reduce the conformation space to a more approachable analog, and their +success depends on striking a useful balance between simplicity and +accuracy. \begin{figure} \begin{center} -- 2.26.2