From 7c7cda0fe44057fd1fe3a84e96a75952ac4d1b82 Mon Sep 17 00:00:00 2001 From: "W. Trevor King" Date: Mon, 25 Jun 2012 19:34:47 -0400 Subject: [PATCH] Point out some early DNA work before introducing titin. --- src/apparatus/polymer-synthesis.tex | 19 +++++++++++-------- 1 file changed, 11 insertions(+), 8 deletions(-) diff --git a/src/apparatus/polymer-synthesis.tex b/src/apparatus/polymer-synthesis.tex index 6a4992a..c6af6bd 100644 --- a/src/apparatus/polymer-synthesis.tex +++ b/src/apparatus/polymer-synthesis.tex @@ -1,14 +1,17 @@ \section{Protein Polymer Synthesis} \label{sec:polymer-synthesis} -Early experiments in force spectroscopy involved native -titin\index{titin}\citep{rief97a}. Titin is a muscle protein involved -in passive elasticity (\cref{fig:skeletal-muscle}), so it is an ideal -subject when examining the effect of mechanical force\citep{labeit95}. -Titin is also interesting because, while it is one of the largest -known proteins, it is composed of a series of globular domains. When -\citet{rief97a} carried out their seminal unfolding experiment, the -observed a very charachteristic sawtooth as the domains unfolded (see +Early experiments in force spectroscopy involved +DNA\citep{bustamante94,florin95}, but before long they were also +investigating proteins. Native titin was one of the first proteins +studied with force spectroscopy\index{titin}\citep{rief97a}. Titin is +a muscle protein involved in passive elasticity +(\cref{fig:skeletal-muscle}), so it is an ideal subject when examining +the effect of mechanical force\citep{labeit95}. Titin is also +interesting because, while it is one of the largest known proteins, it +is composed of a series of globular domains. When \citet{rief97a} +carried out their seminal unfolding experiment, the observed a very +charachteristic sawtooth as the domains unfolded (see \cref{sec:procedure} for a discussion of these sawteeth). \begin{figure} -- 2.26.2