From: W. Trevor King <wking@tremily.us>
Date: Mon, 25 Jun 2012 23:34:47 +0000 (-0400)
Subject: Point out some early DNA work before introducing titin.
X-Git-Tag: v1.0~325
X-Git-Url: http://git.tremily.us/?a=commitdiff_plain;h=7c7cda0fe44057fd1fe3a84e96a75952ac4d1b82;p=thesis.git

Point out some early DNA work before introducing titin.
---

diff --git a/src/apparatus/polymer-synthesis.tex b/src/apparatus/polymer-synthesis.tex
index 6a4992a..c6af6bd 100644
--- a/src/apparatus/polymer-synthesis.tex
+++ b/src/apparatus/polymer-synthesis.tex
@@ -1,14 +1,17 @@
 \section{Protein Polymer Synthesis}
 \label{sec:polymer-synthesis}
 
-Early experiments in force spectroscopy involved native
-titin\index{titin}\citep{rief97a}.  Titin is a muscle protein involved
-in passive elasticity (\cref{fig:skeletal-muscle}), so it is an ideal
-subject when examining the effect of mechanical force\citep{labeit95}.
-Titin is also interesting because, while it is one of the largest
-known proteins, it is composed of a series of globular domains.  When
-\citet{rief97a} carried out their seminal unfolding experiment, the
-observed a very charachteristic sawtooth as the domains unfolded (see
+Early experiments in force spectroscopy involved
+DNA\citep{bustamante94,florin95}, but before long they were also
+investigating proteins.  Native titin was one of the first proteins
+studied with force spectroscopy\index{titin}\citep{rief97a}.  Titin is
+a muscle protein involved in passive elasticity
+(\cref{fig:skeletal-muscle}), so it is an ideal subject when examining
+the effect of mechanical force\citep{labeit95}.  Titin is also
+interesting because, while it is one of the largest known proteins, it
+is composed of a series of globular domains.  When \citet{rief97a}
+carried out their seminal unfolding experiment, the observed a very
+charachteristic sawtooth as the domains unfolded (see
 \cref{sec:procedure} for a discussion of these sawteeth).
 
 \begin{figure}