From: W. Trevor King Date: Thu, 25 Apr 2013 17:07:21 +0000 (-0400) Subject: introduction/main.tex: Tighten single molecule lead-in X-Git-Tag: v1.0~288 X-Git-Url: http://git.tremily.us/?a=commitdiff_plain;h=488a43881fcee8261b32f22933cb926cb3397b91;p=thesis.git introduction/main.tex: Tighten single molecule lead-in Replace "imposes certain limitations on" with "limits" ;). --- diff --git a/src/introduction/main.tex b/src/introduction/main.tex index 20fbb32..f55709d 100644 --- a/src/introduction/main.tex +++ b/src/introduction/main.tex @@ -108,19 +108,18 @@ distinctions in the near future. \section{Single Molecule Protein Folding Studies} \label{sec:single-molecule} -The large size of proteins relative to simpler molecules imposes -certain limitations on the information attainable from bulk -measurements, because the macromolecules in a population can have -diverse conformations and behaviors. Bulk measurements average over -these differences, producing excellent statistics for the mean, but -making it difficult to understand the variation. The individualized, -and sometimes rare, behaviors of macromolecules can have important -implications for their functions inside the cell. Single molecule -techniques, in which the macromolecules are studied one at a time, -allow direct access to the variation within the population without -averaging. This provides important and complementary information -about the functional mechanisms of several biological -systems\citep{bustamante08}. +The large size of proteins relative to simpler molecules limits the +information attainable from bulk measurements, because the +macromolecules in a population can have diverse conformations and +behaviors. Bulk measurements average over these differences, +producing excellent statistics for the mean, but making it difficult +to understand the variation. The individualized, and sometimes rare, +behaviors of macromolecules can have important implications for their +functions inside the cell. Single molecule techniques, in which the +macromolecules are studied one at a time, allow direct access to the +variation within the population without averaging. This provides +important and complementary information about the functional +mechanisms of several biological systems\citep{bustamante08}. Single molecule techniques provide an opportunity to study protein folding and unfolding at the level of a single molecule, where the