theory in the context of thermally activated barrier crossings, which
is how we use it here.
-
-\subsection{Who's who}
-
-The field of mechanical protein unfolding is developing along three main branches.
-Some groups are predominantly theoretical,
-\begin{itemize}
- \item Evans, University of British Columbia (Emeritus) \\
- \url{http://www.physics.ubc.ca/php/directory/research/fac-1p.phtml?entnum=55}
- \item Thirumalai, University of Maryland \\
- \url{http://www.marylandbiophysics.umd.edu/}
- \item Onuchic, University of California, San Diego \\
- \url{http://guara.ucsd.edu/}
- \item Hyeon, Chung-Ang University (Onuchic postdoc, Thirumalai postdoc?) \\
- \url{http://physics.chem.cau.ac.kr/} \\
- \item Dietz (Rief grad) \\
- \url{http://www.hd-web.de/}
- \item Hummer and Szabo, National Institute of Diabetes and Digestive and Kidney Diseases \\
- \url{http://intramural.niddk.nih.gov/research/faculty.asp?People_ID=1615}
- \url{http://intramural.niddk.nih.gov/research/faculty.asp?People_ID=1559}
-\end{itemize}
-and the experimentalists are usually either AFM based
-\begin{itemize}
- \item Rief, Technischen Universität München \\
- \url{http://cell.e22.physik.tu-muenchen.de/gruppematthias/index.html}
- \item Fernandez, Columbia University \\
- \url{http://www.columbia.edu/cu/biology/faculty/fernandez/FernandezLabWebsite/}
- \item Oberhauser, University of Texas Medical Branch (Fernandez postdoc) \\
- \url{http://www.utmb.edu/ncb/Faculty/OberhauserAndres.html}
- \item Marszalek, Duke University (Fernandez postdoc) \\
- \url{http://smfs.pratt.duke.edu/homepage/lab.htm}
- \item Guoliang Yang, Drexel University \\
- \url{http://www.physics.drexel.edu/~gyang/}
- \item Wojcikiewicz, University of Miami \\
- \url{http://chroma.med.miami.edu/physiol/faculty-wojcikiewicz_e.htm}
-\end{itemize}
-or laser-tweezers based
-\begin{itemize}
- \item Bustamante, University of California, Berkley \\
- \url{http://alice.berkeley.edu/}
- \item Forde, Simon Fraser University \\
- \url{http://www.sfu.ca/fordelab/index.html}
-\end{itemize}
-
\subsection{Evolution of unfolding modeling}
Evans introduced the saddle-point Kramers' approximation in a protein unfolding context 1997 (\citet{evans97} Eqn.~3).